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Relationship Between Progression-Free Survival and Overall Survival Benefit: A Simulation Study
Therapeutic Innovation & Regulatory Science, 2013This study evaluated the circumstances under which the observed progression-free survival (PFS) benefit may translate into an overall survival (OS) benefit.A simulation study, based on PFS and OS joint model decomposition, was conducted to evaluate the impact of crossover rates, survival post progression (SPP) lengths, and magnitudes of difference in ...
Lijun, Zhang +3 more
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Progression-Free Survival Is a Surrogate for Survival in Advanced Colorectal Cancer
Journal of Clinical Oncology, 2007Purpose The traditional end point for assessing efficacy of first-line chemotherapies for advanced cancer is overall survival (OS), but this end point requires prolonged follow-up and is potentially confounded by the effects of second-line therapies. We investigated whether progression-free survival (PFS) could be considered a valid surrogate for OS in
Marc, Buyse +8 more
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Valid Analysis of Brain-Specific Progression-Free Survival
JAMA OncologyYuandong, Yu, Fengjun, Cao, Guoxing, Wan
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Cancer treatment and survivorship statistics, 2022
Ca-A Cancer Journal for Clinicians, 2022Kimberly D Miller +2 more
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Management of glioblastoma: State of the art and future directions
Ca-A Cancer Journal for Clinicians, 2020Aaron Tan, David M Ashley, Giselle Lopez
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