Results 101 to 110 of about 7,103 (220)

Mortalidade por esclerose lateral amiotrófica no município de São Paulo de 2002 a 2006 [PDF]

, 2011
OBJECTIVE: To describe the mortality rates of amyotrophic lateral sclerosis (ALS) in the city of São Paulo as a function of demographics, year, and region. METHOD: This was a retrospective descriptive study.
Conde, Mônica Tilli Reis Pessoa, Fontes, Sissy Veloso, Fávero, Francis Meire, Matos, Sheila Evangelista de, Oliveira, Acary Souza Bulle, Quadros, Abrahão Augusto Juviniano, Taniguchi, Mauro   +6 more
core   +2 more sources

A Personal Exploration of Oral Health in Amyotrophic Lateral Sclerosis (ALS) Through the Eyes of a Multifaceted Authority

Journal of Oral Rehabilitation, Volume 53, Issue 5, Page 1059-1064, May 2026.
This study resulted in agendas to improve oral health care, research, and education, advocating for a shift in ALS oral health care: from neglect to proactive integration. ABSTRACT Background and Objective Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that impairs motor function, including oral musculature, complicating
Merel C. Verhoeff, Maurits K. A. van Selms, Frank Lobbezoo   +2 more
wiley   +1 more source

Predicting disease progression in progressive supranuclear palsy in multicenter clinical trials [PDF]

, 2016
INTRODUCTION: Clinical and MRI measurements can track disease progression in PSP, but many have not been extensively evaluated in multicenter clinical trials.
AL-108-231 Investigators, ., Bang, J, Boxer, AL, Doody, RS, Gold, M, Grossman, M, Knopman, DS, Lang, AE, Lees, A, Lobach, IV, Miller, BL, Morimoto, BH, Schneider, LS   +12 more
core   +1 more source

Diagnostic Utility of the ATG9A Ratio in AP‐4–Associated Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, Volume 13, Issue 4, Page 834-839, April 2026.
ABSTRACT Adaptor protein complex 4–associated hereditary spastic paraplegia (AP‐4‐HSP), a childhood‐onset neurogenetic disorder and frequent mimic of cerebral palsy, is caused by biallelic variants in the adaptor protein complex 4 (AP‐4) subunit genes (AP4B1 [for SPG47], AP4M1 [for SPG50], AP4E1 [for SPG51], and AP4S1 [for SPG52]).
Habibah A. P. Agianda, Hyo‐Min Kim, Nicole Battaglia, Joshua Rong, Amy Tam, Enrique Gonzalez Saez‐Diez, Cornelius F. Boerkoel, Afshin Saffari, Vicente Quiroz, Luca Schierbaum, Zainab Zaman, Katerina Bernardi, Darius Ebrahimi‐Fakhari   +12 more
wiley   +1 more source

The clinical spectrum of sporadic and familial forms of frontotemporal dementia [PDF]

, 2016
The term frontotemporal dementia (FTD) describes a clinically, genetically and pathologically diverse group of neurodegenerative disorders. Symptoms of FTD can present in individuals in their twenties through to their nineties, but the mean age at onset ...
Rohrer, JD, Woollacott, IO
core   +1 more source

Glial pathology networks reveal early olfactory vulnerability in post mortem human Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The olfactory system is an early target in Alzheimer's disease (AD), yet regional glial pathology interactions remain poorly defined. We examined how glial activation and pathological burden differ between the olfactory cortex (OC) and olfactory bulb (OB) across disease stages.
Da Hae Jung, Eunji Park, Hyeon Chang Ju, Cheil Moon, Ali Jahanshahi   +4 more
wiley   +1 more source

Olfactory decline tracks central‐to‐peripheral spread of tau pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Olfactory decline often precedes cognitive symptoms in Alzheimer's disease (AD) and is linked to tau pathology. Yet, whether tau aggregates start in peripheral olfactory structures or spread from central regions remains debated. METHODS We analyzed 34 post mortem human olfactory bulb (OB) and 2 neuroepithelium (ONE) samples across
Kamar Bouchoucha, Lisa Collin, Céline Coquette, Lise Colmant, Emilien Boyer, Lara Huyghe, Lisa Quenon, Thomas Gerard, Yasmine Salman, Valérie Hox, Pascal Kienlen‐Campard, Bernard Hanseeuw, Anabelle Decottignies, Caroline Huart   +13 more
wiley   +1 more source

Decision-making and referral processes for patients with motor neurone disease: a qualitative study of GP experiences and evaluation of a new decision-support tool [PDF]

, 2017
Background The diagnosis of motor neurone disease (MND) is known to be challenging and there may be delay in patients receiving a correct diagnosis. This study investigated the referral process for patients who had been diagnosed with MND, and whether a
Susan Baxter, Christopher J. McDermott, C Jackson, S Bourke, CJ McDermott, MR O’Brien, M Kraemer, E Househam, J Mason, M Galvin, C Foot, K Talbot, L Blank, VL Allgar, GA Abel, DW Green, J Moffat, VA Hill   +17 more
core   +3 more sources

INCIDENCE OF AMYOTROPHIC LATERAL SCLEROSIS IN SICILY: A POPULATION BASED STUDY. [PDF]

, 2012
Our objective was to investigate incidence of amyotrophic lateral sclerosis (ALS) in Sicily, southern Italy, by means of a population based study. We included people with ALS resident in fi ve Sicilian provinces, whose onset occurred in the two-year ...
ARIDON, Paolo, Cellura, E, D'AMELIO, Marco, LA BELLA, Vincenzo, Maimone, D, RAGONESE, Paolo, SAVETTIERI, Giovanni, SPATARO, Rossella, TAIELLO, Alfonsa Claudia   +8 more
core   +1 more source

Hereditary spastic paraplegia: Identification of an SPG3A gene mutation in a Chinese family [PDF]

, 2009
Hereditary spastic paraplegias are a heterogeneous group of chronic central motor system disorders, characterised by progressive lower limb spasticity. Hereditary spastic paraplegia is clinically classified into pure and complicated forms, by the absence
Chan, AYW, Chan, KY, Ching, CK, Lam, CW, Mak, CM   +4 more
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