Results 41 to 50 of about 320,938 (307)

Overall buckling of lightweight stiffened panels using an adapted orthotropic plate method

open access: yes, 2015
The ultimate longitudinal bending strength of thin plated steel structures such as box girder bridges and ship hulls can be determined using an incremental–iterative procedure known as the Smith progressive collapse method.
Benson, S., Dow, R.S., Downes, J.
core   +1 more source

Vulnerability Assessment of Building Frames Subjected to Progressive Collapse Caused by Earthquake [PDF]

open access: yes, 2017
Progressive collapse is an initial local failure of the structural component and leading to the additional collapse of the building frames. This study investigated the vulnerability of four- and six-storey moment resisting concrete frame (MRCF ...
Mansor, Hazrina   +3 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimisation of Cable Dome Structure Design for Progressive Collapse Resistance

open access: yesApplied Sciences, 2023
Since the literature lacks an effective analysis method of collapse mechanisms and optimisation design theory for progressive collapse resistance of cable dome structure, a structural performance-based optimisation approach was proposed to improve the ...
Lian-Meng Chen   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Parametric study of the load-bearing mechanisms in RC beam-grids to resist progressive collapse [PDF]

open access: yes, 2019
Recently, several structural failures demonstrated the disastrous consequences of progressive collapse and raised the awareness of the engineering community.
Botte, Wouter   +2 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Diffraction-Unlimited Position Measurement of Ultracold Atoms in an Optical Lattice

open access: yes, 2015
We consider a method of high-fidelity, spatially resolved position measurement of ultracold atoms in an optical lattice. We show that the atom-number distribution can be nondestructively determined at a spatial resolution beyond the diffraction limit by ...
Ashida, Yuto, Ueda, Masahito
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Progressive Collapse Resistance of RC Beam–Slab Substructures Made with Rubberized Concrete

open access: yesBuildings, 2022
Abnormal loads can produce localized damage that can eventually cause progressive collapse of the whole reinforced concrete (RC) structure. This might have devastating financial repercussions and cause numerous severe casualties.
Ibrahim M. H. Alshaikh   +5 more
doaj   +1 more source

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