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Natalizumab-associated progressive multifocal leukoencephalopathy in Germany
Neurology, 2019Objective To evaluate characteristics relevant to diagnosis of JC polyomavirus-associated progressive multifocal leukoencephalopathy (PML), and PML risk stratification in a large national cohort of patients with multiple sclerosis during therapy with ...
Kira Blankenbach +5 more
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Progressive Multifocal Leukoencephalopathy
Pathology, 2014Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system that is caused by reactivation of the polyoma virus JC (JC virus). Asymptomatic primary infection with JC virus occurs in childhood and antibodies can be found in 86% of adults.
Tayyaba Khan, Winny Varikatt
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Progressive Multifocal Leukoencephalopathy
New England Journal of Medicine, 1961IN the course of the regular post-mortem examination of the brains of patients coming to autopsy at the Massachusetts General Hospital, my attention has been called in recent years to an unusual disorder of the cerebral white matter with distinctive features unfamiliar to me and my colleagues from our own experience or that of others.
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Progressive multifocal leukoencephalopathy
European Journal of Radiology Extra, 2006Abstract Progressive multifocal leukoencephalopathy (PML) is a fulminating opportunistic infection of the brain that occurs in approximately 4% of AIDS patients. The need to diagnose and treat PML is urgent in patients with HIV as the infections are synergistic [Vazeux R, Cumont M, Girard P, et al. Severe encephalitis resulting from co-infection with
Ravinder Sidhu, Ajay Malhotra
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Progressive multifocal leukoencephalopathy [PDF]
Neurology, 1965 Robert M. Woolsey, James S. Nelson
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Natalizumab and Progressive Multifocal Leukoencephalopathy
New England Journal of Medicine, 2005The Brief Reports on natalizumab were referred to Biogen Idec, the manufacturer, which offers the following response: After learning of one confirmed and one suspected case of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab, Biogen Idec and Elan quickly notified the Food and Drug Administration (FDA) and other ...
Alfred Sandrock +2 more
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Progressive multifocal leukoencephalopathy and natalizumab
Journal of Neurology, 2011Natalizumab (TYSABRI(®)), a specific α4-integrin antagonist, is approved as a second-line treatment of relapsing-remitting MS (RRMS) patients who fail therapy with interferons or as first-line treatment of patients with highly active relapsing-remitting disease. Since the market introduction of natalizumab as a monotherapy in July of 2006, 111 cases of
Ralf Gold, Kerstin Hellwig
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Progressive multifocal leukoencephalopathy in HIV
International Journal of STD and AIDS, 1997Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by infection of oligodendrocytes by JC virus. As patients with HIV survive longer with severe immunodeficiency, the incidence of PML is rising.
M Sadler, M R Nelson
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Viruses and Progressive Multifocal Leukoencephalopathy
New England Journal of Medicine, 1972There has recently been an increasing interest in the relation between viruses and chronic degenerative diseases of the brain. Within the past few years, measles virus has been found to be associated with subacute sclerosing panencephalitis and transmissible agents have been isolated from patients with Kuru and Creutzfeldt—Jakob disease (spongiform ...
Martin S. Hirsch, Paul H. Black
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Progressive Multifocal Leukoencephalopathy: What’s New?
The Neuroscientist, 2010Progressive multifocal leukoencephalopathy (PML), a severe demyelinating disease that is caused by human JC polyomavirus, was first described as a complication of immune suppression 50 years ago and emerged as a major complication of HIV infection in the 1980s.
Focosi D +5 more
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