The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity
Molecular Oncology, EarlyView.Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause +6 more
wiley +1 more source
Effectiveness- and cost effectiveness of a structured method for systematic and integrated occupational safety and health and patient safety management systems (SIOHPS) - a study protocol for a pragmatic stepped wedge cluster randomised controlled trial. [PDF]
BMC Health Serv ResLohela-Karlsson M +7 more
europepmc +1 more source
Report of the Thirteenth Session of the JSC/CLIVAR Working Group on Coupled Modelling (WGCM), 28-30 September 2009, San Francisco, USA [PDF]
, 2010 International CLIVAR Project Office
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Construction of a practice model of evidence-based health service development for public health nursing in Japan: a Delphi survey. [PDF]
BMC NursOkamoto R +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
On the imbeddings of abstract surfaces in projective varieties [PDF]
, 1957 Masayoshi Nagata
openalex +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Community Cancer Champions' Project: Learning From the Design and Implementation of an Integrated Health and Voluntary and Community Sector (VCS) Asset-Based Community Development Project - A Case Study From Plymouth, England. [PDF]
Int J Integr CareStevenson K +4 more
europepmc +1 more source