Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Risk network analysis and simulation research in municipal engineering projects contracted by China in Saudi Arabia. [PDF]
Alotaibi RTT.
europepmc +1 more source
Report of the Thirteenth Session of the JSC/CLIVAR Working Group on Coupled Modelling (WGCM), 28-30 September 2009, San Francisco, USA [PDF]
International CLIVAR Project Office
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The efficacy and safety of lower-dose aspirin for primary and secondary prevention of cardiovascular disease in the elderly: an interim analysis of a multicenter, prospective, observational study. [PDF]
Wang X +41 more
europepmc +1 more source
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
The ART of evidence-based care: proof of concept of a novel strategy to accelerate research translation in health organisations. [PDF]
Harding KE +8 more
europepmc +1 more source
$sup 235$U--THORIUM FUEL CYCLES IN GRAPHITE MODERATED SYSTEMS. Project DRAGON.
J. Blomstrand +4 more
openalex +1 more source

