Results 131 to 140 of about 20,529,932 (305)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Project technologies as a factor in the development of students’ creative potential
Вестник Тамбовского университета. Серия: Гуманитарные наукиImportance. The demand for a creative approach in many fields of activity is revealed, and creativity is also considered as a necessary part of professional training. The actualization of active methods (using the example of project technologies) for the
E. I. Grigorieva, M. V. Sakharova
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Вестник Тамбовского университета. Серия: Гуманитарные наукиIt is proved that the fundamental purpose of teaching a foreign language is the formation of a foreign language communicative competence, that is, the ability to communicate with representatives of a foreign language culture, within which it is necessary
N. A. Goncharova, A. V. Medvedev
doaj +1 more source
Project activity in educational institutions [PDF]
, 2018 У робочій навчальній програмі подано мету, зміст та завдання вивчення дисципліни "Проектна діяльність у навчальних закладах"В рабочей учебной программе представлены цели, содержание и задачи изучения дисциплины "Проектная деятельность в учебных ...
Ліннік, Олена Олегівна
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Local search methods for the discrete time/resource trade-off problem in project networks. [PDF]
: In this paper we consider the discrete time/resource trade-off problem in project networks. Given a project network consisting of nodes (activities) and arcs (technological precedence relations specifying that an activity can only start when al of its ...
De Reyck, B, Demeulemeester, Erik
core
The STCC Science Teaching Intern Project [PDF]
, 2000 The Springfield Technical Community College (STCC) Science Teaching Intern Project was implemented as a pilot study to give community college students an opportunity to experience science teaching.
Rapoport, N.
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source