Results 181 to 190 of about 20,529,932 (305)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Association between physical activity, sleep quality and diabetes: a population-based analysis. [PDF]

Diabetol Metab Syndr
Liu Y, Chen F, Yin Y, Deng L, Wang W, Fan J.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Reconstructing schoolyards with greenery to increase schoolchildren's physical activity and mitigate climate changes in urban areas: study protocol for a stepped-wedge trial. [PDF]

BMC Public Health
Wilén C, Ahlqvist VH, Migueles JH, Campos-Garzón P, Dahlén M, Kosidou K, Rådholm K, Henriksson P, Berglind D.   +8 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Farm-based therapeutic horticulture for people living with dementia: the Vicenza Farm Project. [PDF]

Front Dement
Dalla Costa L, Meneghello F, Righetto C, Senes G.   +3 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Knocking Down miR172f in the Hairy Roots of Grass Pea Increases β-ODAP Content and Induces Global Transcriptomic Reprogramming. [PDF]

Genes (Basel)
Liu X, Zhang X, Bai J, Lv J, Jiang Y, Zhan J, Yang Z, Han R, You T, Ma H, Cao N, Lian R, Wang S, Yue Y, Xu Q.   +14 more
europepmc   +1 more source

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

Proceedings of the National Academy of Sciences of the United States of America, 1998
L. Lecea, T. Kilduff, C. Peyron, Xiao-Bing Gao, P. E. Foye, P. Danielson, C. Fukuhara, E. Battenberg, V. Gautvik, F. S. Bartlett, W. Frankel, A. Pol, F. Bloom, K. Gautvik, J. Sutcliffe   +14 more
semanticscholar   +1 more source