Results 121 to 130 of about 167,409 (351)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Design and Application of Energy Recovery System for AC Diesel Engine Test Platform

机车电传动, 2015
The diesel engine of AC diesel locomotive would generate huge of electricity energy during the maintenance and commissioning process. In order to recover those energy, the energy storage and novel power electronics topology based energy recovering system
WU Tong, ZHOU You, NIU Jianna
doaj  

Development and Validation of Digital Twin Behavioural Model for Virtual Commissioning of Cyber-Physical System

Applied Sciences
Modern manufacturing systems are influenced by the growing complexity of mechatronics, control systems, IIoT, and communication technologies integrated into cyber-physical systems. These systems demand flexibility, modularity, and rapid project execution,
Roman Ruzarovsky, Tibor Horak, Roman Zelník, Richard Skypala, Martin Csekei, Ján Šido, Eduard Nemlaha, Michal Kopcek   +7 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The Role Of Monitoring And Evaluation In Donor Funded Government Projects: The Case Of Oromia Pastoral Area Development Coordination Commission

, 2019
Wake, Jemaneh
openalex   +1 more source

Commission on Spin, Charge and Momentum Density. Project No. 1. Standardization of Compton profile measurements – The Compton profile of water [PDF]

, 1976
Brian Williams
openalex   +1 more source

An Engaged Learning Project Incorporating the CGMA Framework Knowledge Skills, Pathways Commission Learning Objectives, and AICPA Framework Core Competencies Utilized in an Accounting II(III) Course at Two Universities [PDF]

, 2020
Judith A. Sage, Lloyd G. Sage
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Commission decision on the Northern California Power Agency's Application for Certification for Geothermal Project No. 2. Docket 79-AFC-2

, 1980
California Energy Commission, Sacramento (USA)
openalex   +2 more sources

Commissioning of Water Supply and Sanitation Projects- A Case from Nepal

, 2023
Ashutosh Mishra, Pralad Nepali, Mukti Nath Jha, P. S. Aithal   +3 more
openalex   +1 more source