Results 41 to 50 of about 4,645,684 (346)

Hybrid organizations as a strategy for supporting new product development [PDF]

open access: yes, 2005
Alliances between large, well-established corporations and highly creative small companies or consultancies can be an effective method for promoting ...
Gander, Jonathan   +2 more
core   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

open access: yesFEBS Letters, EarlyView.
Accurate protein synthesis is crucial for life. The key players are aminoacyl‐tRNA synthetases (AARSs), which read the genetic code by pairing cognate amino acids and tRNAs. AARSs establish high amino acid selectivity by employing physicochemical limits in molecular recognition.
Igor Zivkovic   +2 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Investigation and evaluation of construction and commissioning risks in construction projects (Case Study: Hospital) [PDF]

open access: yesمهندسی و مدیریت ساخت, 2017
One of the most important project management areas is project risks management. This area of project management knowledge, give manager the power to improve project performance.
Ibrahim Abdolahnejad   +2 more
doaj  

Trends and Perspectives on Digital Platforms and Digital Television in Europe| Commissioning and Independent Television Production: Power, Risk, and Creativity

open access: yesInternational Journal of Communication, 2022
Project development—the initial stage of television production—establishes the aesthetic and narrative parameters for the final on-screen representations.
Anna Zoellner
doaj  

Preparation and Commissioning for the LHD Deuterium Experiment

open access: yesIEEE Transactions on Plasma Science, 2018
The deuterium experiment started from March 2017 on the large helical device (LHD) as a part of the LHD high-performance upgrade project. The objectives of the deuterium experiment are: 1) to realize the high-performance operation; 2) to explore the ...
M. Osakabe   +7 more
semanticscholar   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Primary care-led commissioning and public involvement in the English National Health Service. Lessons from the past. [PDF]

open access: yes, 2014
Background: Patient and Public involvement (PPI) in health care occupies a central place in Western democracies. In England, this theme has been continuously prominent since the introduction of market reforms in the early 1990s.
Peckham, Stephen   +3 more
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

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