Results 71 to 80 of about 167,409 (351)

Commission problems and countermeasures of integrated membrane technology in boiler make-up water system of a power plant

Gongye shui chuli
Based on the technical renovation project of boiler make-up water system in a power plant in North China，the design characteristics and operation mode of ultrafiltration-first stage reverse osmosis-second stage reverse osmosis-electrodeionization（EDI ...
ZHANG Kai, CHEN Yuqiang, CHEN Yang, LI Xiaojun, WANG Niuwang, LIU Guidong, HU Mingrui   +6 more
doaj   +1 more source

The other GMP: good manufacturing practice and its importance in the validation of constructed pharmaceutical facilities [PDF]

, 2005
The work reported is part of an ongoing PhD study prompted by the particular difficulties encountered when two very different quality cultures interact (in this case Pharmaceutical industry clients and Construction industry providers).
Edge, Jerry, Greenwood, David, Render, Neil   +2 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

CERN ELENA project progress report

EPJ Web of Conferences, 2015
The Extra Low Energy Antiproton ring (ELENA) is a CERN project aiming at constructing a 30 m circumference synchrotron to further decelerate antiprotons from the Antiproton Decelerator (AD) from 5.3 MeV to 100 keV.
Bartmann Wolfgang, Belochitskii Pavel, Breuker Horst, Butin François, Carli C., Eriksson Tommy, Oelert Walter, Maury Stephan, Pasinelli Sergio, Tranquille Gerard   +9 more
doaj   +2 more sources

Research on Engineering Acceptance Measures and Safety Evaluation Schemes of City Railway New Projects in Shanghai

Chengshi guidao jiaotong yanjiu
Objective Several projects of city railway in Shanghai are currently under construction. However, there are no well-defined engineering acceptance and safety evaluation management measures for new city railway projects at the moment.
Zhiping LIU, Yang LIU
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Cybernetic Model Design for the Qualification of Pharmaceutical Facilities

Applied Sciences
In this paper, an integrated cybernetic model for managing qualification activities when commissioning pharmaceutical facilities is created, focusing on defining critical factors that provide all the prerequisites for the start of the production process.
Ilija Tabasevic, Dragan D. Milanovic, Vesna Spasojevic Brkic, Mirjana Misita, Aleksandar Zunjic   +4 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Commissioning and co‐production in health and care services in the United Kingdom and Ireland: An exploratory literature review

Health Expectations
Introduction This exploratory literature review seeks to examine the literature around commissioning processes in the co‐production of health and care services, focusing on two questions: How do health and care commissioning processes facilitate and/or ...
Rebecca J. Scott, Elspeth Mathie, Hannah J. H. Newman, Kathryn Almack, Louca‐Mai Brady   +4 more
doaj   +1 more source