Results 91 to 100 of about 7,578,805 (306)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Malaria JournalBackground Continuous distribution of insecticide treated nets (ITNs) through schools is increasingly utilized by National Malaria Programmes across sub-Saharan Africa to maintain coverage between three-year mass distribution campaigns.
Keith Esch +19 more
doaj +1 more source
Lifestyle and Income-related Inequality in Health in South Africa
International Journal for Equity in Health, 2017 Background Many low- and middle-income countries are experiencing an epidemiological transition from communicable to non-communicable diseases. This has negative consequences for their human capital development, and imposes a growing economic burden on ...
Alfred Kechia Mukong +2 more
doaj +1 more source
Learning about End-User Development for Smart Homes by "Eating Our Own Dog Food" [PDF]
, 2015 SPOK is an End-User Development Environment that permits people to monitor, control, and configure smart home services and devices. SPOK has been deployed for more than 4 months in the homes of 5 project team members for testing and refinement, prior to ...
Coutaz, Joelle, Crowley, James L.
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
CONTRIBUTION TO THEORETICAL AND PRACTICAL DEVELOPMENT OF MINING PROJECTING
Rudarsko-geološko-naftni Zbornik, 1995 Mining project is a directive and guiding principle of all activities in practice and it is generaly not evaluated corresponding wilh its significance. There is a risk present in project grounds. Minimun investigation is prescribed.
Jerko Nuić, Andrija Mikulić
doaj
Guideline for handling pesticide residues in Czech organic production [PDF]
, 2013 This document was prepared in the project «Development of guidelines for the use of pesticide analysis in organic inspection in the Czech Republic (sampling, evaluation and interpretation)». At the beginning of this project, a workshop with stakeholders
Bickel, Regula +3 more
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