Results 101 to 110 of about 664,622 (304)

Limited Liability and Option Contracts in Models with Sequential Investments [PDF]

The paper investigates a model where two parties sequentially invest in a joint project (an asset). Investments and the project value are unverifiable, and A is wealth constrained so that an initial outlay must be financed by either agent B or an ...
Christoph Lülfesmann
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

How backers' behavior affects financing performance in agri-food reward-based crowdfunding: The moderating mechanism of initiator characteristics and project attributes.

PLoS ONE
Crowdfunding is a new type of financing favored by entrepreneurs in need of capital. Financing performance is a key concern for crowdfunding project initiators.
Junjuan Du
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Healthcare Digitalization and Pay-For-Performance Incentives in Smart Hospital Project Financing. [PDF]

Int J Environ Res Public Health, 2020
Moro Visconti R, Morea D.
europepmc   +1 more source

Irrigation management transfer in the Columbia Basin: lessons and international implications [PDF]

Irrigation management, Farmer managed irrigation systems, Privatization, Irrigation efficiency, Irrigation effects, Project appraisal, Financing, Developing countries, Farm Management, Financial Economics,
Svendsen, Mark, Vermillion, Douglas Lynn
core   +1 more source

A Decision-Support Framework For Using Value Capture to Fund Public Transit: Lessons From Project-Specific Analyses, Research Report 11-14 [PDF]

, 2012
Local and state governments provide 75 percent of transit funds in the United States. With all levels of governments under significant fiscal stress, any new transit funding mechanism is welcome. Value capture (VC) is one such mechanism.
Mathur, Shishir, Smith, Adam
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Association Between User Fees and Dropout from Methadone Maintenance Therapy: Results of a Cohort Study in Vietnam

Health Systems & Reform, 2018
—Vietnam launched methadone maintenance therapy (MMT) in 2008 with donor funding. To expand and ensure sustainability of the program, Vietnam shifted the responsibility for financing portions of MMT to provinces and, in 2015, some provinces started ...
Benjamin Johns, Le Bao Chau, Kieu Huu Hanh, Pham Duc Manh, Hoa Mai Do, Anh Thuy Duong, Long Hoang Nguyen   +6 more
doaj   +1 more source

Pay for Success: The First Generation - A Comparative Analysis of the First 10 Pay for Success Projects in the United States [PDF]

, 2016
Nonprofit Finance Fund (NFF) has released a comprehensive free report on the first 10 Pay for Success (PFS) projects that have launched in the United States.
Dana Archer-Rosenthal
core