Results 61 to 70 of about 18,981,807 (305)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

State of the Art: Building-Integrated Photovoltaic (BIPV) Products

Applied Sciences
Building-integrated photovoltaic (BIPV) systems offer a promising pathway for embedding renewable energy generation into the built environment. However, their widespread adoption is hindered by inconsistent, incomplete, and non-standardized product ...
Rebecca Jing Yang, Yusen Zhao, Chaoxiang Zhang, Chathuri Gunarathna, Pabasara Wijeratne, Jiaqi Yang, Nilmini Pradeepika Weerasinghe, Yukun Zang, Hongying Zhao, Tharushi Samarasinghalage, Chengyang Liu, Sajani Jayasuriya, Mathanky Sachchithananthan   +12 more
doaj   +1 more source

Development of multifunctional software for business operations in SMEs [PDF]

Tehnika, 2016
This paper presents the web-oriented software solution focused on supporting the efficient management of operations and projects in SMEs. The development of this software is treated as a separate project and has used agile software development ...
Berić Ivana M., Jovanović Aca D., Popović Milan M., Radulović Aleksandar V.   +3 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Dispatcher3 D8.1 - Project management plan

, 2020
This document is the Project Management Plan (PMP) of the Clean Sky 2 Innovation Action Dispatcher3. The PMP documents the management plan and procedures, complementing the project information provided in the Grant Agreement Description of Action with ...
Delgado, L., Valput, D., Tanner, G.
core   +2 more sources

Impact of irrigation and crop residue management on maize (Zea mays)– chickpea (Cicer arietinum) sequence under no tillage conditions

The Indian Journal of Agricultural Sciences, 2014
A field experiment was conducted during 2007-08 and 2010-11 at Belvatagi, Karnataka to study the effect of irrigation and crop residue mulching on water use efficiency and yield of maize (Zea mays L.) - chickpea (Cicer arietinum L.) sequence under no ...
S RAJKUMARA, S S GUNDLUR, J K NEELAKANTH, P ASHOKA   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source