Results 91 to 100 of about 18,981,807 (305)

Preliminary Decision‐Making Processes in Suburban Residential Developments

Urban Planning
German metropolitan regions experience simultaneous reurbanisation in core cities and intensified suburbanisation in surrounding municipalities. Given limited peripheral administrative resources and complex land availability, a fundamental question ...
Stephan Große, Thomas Krüger
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

An exploratory study of capacity building for circular economy transitions in the built environment of the global south

Discover Sustainability
Accelerating transitions toward a circular economy (CE) in the built environment is crucial for advancing sustainable development, particularly in regions where institutional capacity and technical readiness often lag policy ambition. This paper presents
Janappriya Jayawardana, Usha Iyer-Raniga, Akvan Gajanayake   +2 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Managing projects in africa: essentials from the Project Management Journal

, 2013
This special issue of the Project Management Journal presents a collection of six articles on managing projects in Africa. Providing a window into the important project activity taking place there, these articles extend both the empirical and theoretical
Project Management Institute
core  

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Contextual Intelligence in Programme and Project Management: A preliminary framework for configuring resources to meet strategic objectives [PDF]

, 2009
Additional research, design and data collection was carried out by David Partington and Arnoud Franken, Cranfield School of ManagementThe purpose of this paper is twofold.
Murray-Webster, Ruth, Lupson, Jonathan, Geraldi, Joana, Maylor, Harvey, Giudici, Alessandro   +4 more
core   +3 more sources

Assessment of Project Risk Performance of Selected Mass Housing Infrastructures in Northern Nigeria

CSID Journal of Infrastructure Development
Mass housing projects in Northern Nigeria often suffer from insufficient risk management, impacting timely delivery, budget adherence, and quality standards.
Chinedu Chimdi Adindu, Abdulhaqq Onoruoyiza Muhammed, Emmanuel Ashem Egila, Musa Mohammed   +3 more
doaj   +1 more source

Bridging Gaps in Carbon Emission Assessment: Optimization Strategies for Industrial Parks [PDF]

E3S Web of Conferences
Global climate change necessitates urgent carbon emission reductions, with industrial parks (IP) being significant contributors. Existing evaluation methods often underestimate emissions by overlooking direct industrial processes.
Huang Junzhong, Tao Xuejun
doaj   +1 more source