Results 81 to 90 of about 1,266,934 (265)

Challenges for Improvement of Quality in Construction of a Growing Economy [PDF]

Journal of Design and the Built Environment, 2005
This paper highlights the results of a questionnaire survey amongst contractors and contracting consultants in a growing economy. The survey was intended to explore the problems that the employees think might affect the quality of construction works ...
S. Chan Loong, H. Abdul Rahman, F. A. Mohd Rahim, S. Ismail, M. S. Mohd Danuri   +4 more
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Interaction researching mental spaces of movable context, stakeholders, and project manager

Organization, Technology and Management in Construction: An International Journal, 2018
As practice shows, the success of project imple­mentation depends on the clear and integrated interac­tion between stakeholders, the project manager, and the movable context. Such an interaction exists on the level of mental spaces.
Verenych Olena, Bushuyev Sergey
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Exploring the Factors Influencing Project Management Methodology Implementation in Local Governments

Administrative Sciences
This study seeks to identify the factors influencing the implementation of Project Management Methodologies (PMM) in Local Government (LG) and identify the concepts, themes and characteristics that make up each of those factors.
Raj Ranasinghe, Farshid Rahmani, Guinevere Gilbert, Ehsan Gharaie   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Complexity in Project Management

Procedia Computer Science, 2017
Understanding complexity is of significance importance for project managers because of the differences associated with decision making and goal attainment that appear to be related to complex projects. As projects have become more and more complex there has been an increasing concern about the concept of project complexity as it influences upon the ...
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Factors Impacting Viral Load Suppression in Children and Adolescents Living with HIV Enrolled in an Orphans and Vulnerable Children Program in Northeast Nigeria

HIV/AIDS: Research and Palliative Care
Joseph Fabian Inyang,1 Jimin James Sontyo,1 Ayokunle Bello,1 Kabiru Suru Usman,2 Tosin Awele Idaboh,3 Doreen Magaji,3 Moses Katbi3 1Integrated Child Health and Social Service Award − 4, Project ProHealth International, Abuja, Nigeria; 2Integrated Child ...
Inyang JF, Sontyo JJ, Bello A, Usman KS, Idaboh TA, Magaji D, Katbi M   +6 more
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