Results 111 to 120 of about 18,067,850 (306)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Contextual Intelligence in Programme and Project Management: A preliminary framework for configuring resources to meet strategic objectives [PDF]

, 2009
Additional research, design and data collection was carried out by David Partington and Arnoud Franken, Cranfield School of ManagementThe purpose of this paper is twofold.
Murray-Webster, Ruth, Lupson, Jonathan, Geraldi, Joana, Maylor, Harvey, Giudici, Alessandro   +4 more
core   +2 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Understanding the very nature of Project Management : a praxiological approach [PDF]

, 2005
Foreword: In this paper I call upon a praxiological approach. Praxeology (early alteration of praxiology) is the study of human action and conduct. The name praxeology/praxiologyakes is root in praxis, Medieval Latin, from Greek, doing, action, from ...
Bredillet, Christophe
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Dual Model for International Roughness Index Classification and Prediction

Infrastructures
Existing models for predicting the international roughness index (IRI) of a road surface often lack adaptability, struggling to accurately reflect variations in climate, traffic, and pavement distresses—factors critical for effective and sustainable ...
Noelia Molinero-Pérez, Laura Montalbán-Domingo, Amalia Sanz-Benlloch, Tatiana García-Segura   +3 more
doaj   +1 more source

Eyes Wide Shut: Expanding the view of portfolio management [PDF]

, 2011
This conceptual paper examines our existing world-view portfolio is defined the management of that portfolios from that of project and new product development portfolios to other portfolios that exist in an organisation, such as the asset portfolio ...
Young, M, Young, R, Killen, CP
core  

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Exploring the Factors Influencing Project Management Methodology Implementation in Local Governments

Administrative Sciences
This study seeks to identify the factors influencing the implementation of Project Management Methodologies (PMM) in Local Government (LG) and identify the concepts, themes and characteristics that make up each of those factors.
Raj Ranasinghe, Farshid Rahmani, Guinevere Gilbert, Ehsan Gharaie   +3 more
doaj   +1 more source

Challenges for Improvement of Quality in Construction of a Growing Economy [PDF]

Journal of Design and the Built Environment, 2005
This paper highlights the results of a questionnaire survey amongst contractors and contracting consultants in a growing economy. The survey was intended to explore the problems that the employees think might affect the quality of construction works ...
S. Chan Loong, H. Abdul Rahman, F. A. Mohd Rahim, S. Ismail, M. S. Mohd Danuri   +4 more
doaj