Results 121 to 130 of about 1,961,317 (312)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

On-Line Resource Clearinghouse for Rapidly Growing Communities [PDF]

, 2004
According to the Environmental Protection Agency, sprawl is among the biggest environmental challenges facing New England, where more than 1,200 acres of open space are lost to development each week.
Seif, Amy
core   +1 more source

Developing a Maturity Rating System for Project Management Offices

Systems
Effective project management is crucial for organizations to achieve strategic objectives and maintain competitiveness in today’s market. The project management office (PMO) has emerged as a key enabler in enhancing project management effectiveness ...
Abdullah M. Alshabragi, Abdulmohsen S. Almohsen, Abdulrahman A. Bin Mahmoud   +2 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

General practitioner-centered rural obesity management: Design, protocol and baseline data of the German HAPpEN pragmatic trial

Preventive Medicine Reports
Objective: HAPpEN aims to implement and evaluate a holistic general practitioner-centered, interdisciplinary obesity management strategy in rural Germany, focusing on feasibility, health outcomes, and economic benefits.
Marika Haderer, Reiner Hofmann, Tina Bartelmeß, Laura König, Constanze Betz, Mirna Al Masri, Alisa Bader, Natascha von Schau   +7 more
doaj   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

Проектний офіс як центр компетенцій управління розвитком підприємства [PDF]

Усвідомлений синергізм проектного підходу до розвитку компанії вимагає системного управління знаннями компанії в галузі проектного менеджменту. Це є притаманним як для проектно-залежних, так і для проектно-орієнтованих компаній.
Skityova, Ganna, Скитьова, Ганна Сергіївна, Скитёва, Анна Сергеевна   +2 more
core  

Strategic Assessment of Near Coastal Waters: Northeast Case Study [PDF]

, 1988
The Northeast Case Study has been undertaken to illustrate how data being developed in NOAA\u27s program of strategic assessments can be used for resource assessments of estuaries and near coastal waters throughout the contiguous USA.
NOAA/EPA Team on Near Coastal Waters
core   +3 more sources

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source

Propuesta de Creación de una Oficina para el Manejo de Proyectos (PMO) en la Compañía ABC [PDF]

, 2012
Proyecto de Graduación (Maestría en Gerencia de Proyectos) Instituto Tecnológico de Costa Rica, Área Académica de Gerencia de Proyectos, 2012.This research proposes the creation of a Project Management Office planned in the Sales, Distribution and ...
Navarro-Varela, Allan, Ramírez-Mota, Jennifer   +1 more
core