Results 151 to 160 of about 10,395,035 (294)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Process evaluation of the randomized trial-"Care management for older people with cognitive impairment during and after hospitalisation in Germany (intersec-CM)". [PDF]

Trials
Chikhradze N, Hannich A, Otte IC, Busse TS, Suslow A, Nikelski A, Schumacher-Schoenert F, Kreisel SH, Boekholt M, Thyrian JR, Hoffmann W, Vollmar HC.   +11 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Leder

Geoforum Perspektiv, 2016
Line Hvingel, Jakob Fredslund
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Investigating effect versus impact in a participatory action research project: Building end-of-life communication competence in residential care facilities for older people. [PDF]

Palliat Care Soc Pract
Mikaelsson Å, Tishelman C, Noonan K, Kowalski L, Kleijberg M, Johansson T, Stenfors T, Eriksson LE, Goliath I.   +8 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

From Theory to Practice: A Qualitative Study Exploring Change Managers' Experiences Applying Change Management Frameworks in Hospital Redevelopment Across One Australian State. [PDF]

J Healthc Leadersh
Osman S, Chauhan A, Adams C, Cardenas A, Moscova M, Churruca K, Sabesan S, Bhonagiri D, Manias E, Mitchell RJ, Taylor N, Harrison R.   +11 more
europepmc   +1 more source

Project management

, 2006
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source