Results 231 to 240 of about 10,395,035 (294)

Stakeholder perspectives on job analysis for disability-inclusive sewing employment in China: a qualitative content analysis. [PDF]

Front Rehabil Sci
Hu H, Wan Z, Ng PHF, Liu KPY, Fu EY, Cheng ASK.   +5 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Correction: Meningococcal carriage in adolescents and young adults in Kuwait. [PDF]

Front Public Health
Alghounaim M, Bastaki H, Egaila M, Onwumeh-Okwundu J, Abdel Aziz M, Joury J, Sierra L, D'Hellencourt FL.   +7 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Application of the STAT model for demand management to reduce specialist clinic waiting times: protocol for the WaitLESS stepped wedge cluster randomised controlled trial. [PDF]

BMJ Open
Harding KE, Carney P, Lewis AK, Considine J, Brusco N, Prendergast L, Snowdon D, Sarkies MN, Choi P, Bould E, Taylor NF.   +10 more
europepmc   +1 more source

Sharing Back, Listening Forward: Participatory Dissemination in a Tribal Community. [PDF]

J Particip Res Methods
Skewes MC, Gameon JA, FireMoon P.
europepmc   +1 more source

Aging in place preferences of older adults with cognitive impairment and informal caregivers: A qualitative analysis of a discrete choice experiment. [PDF]

J Alzheimers Dis
El Jaouhari S, Geetan C, Farousi B, Pilli LI, Neal D, Engelsma T, Vullings I, Uysal-Bozkir Ö, Van Deudekom F, Muller M, Vroomen JM.   +10 more
europepmc   +1 more source

The role of Advanced Practice Providers in improving primary care capacity: practice perspectives on challenges and opportunities. [PDF]

Front Med (Lausanne)
Shoen M, Webel B, Britz J, Hoffman H, Gilbert J, Krist AH, Brooks EM.   +6 more
europepmc   +1 more source