Results 71 to 80 of about 10,395,035 (294)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

CRIAQ and CARIC: An Innovation Journey - Insights on How to Build Successful Research and Development Collaborations in Aerospace: The Case of the Quebec and Canadian Ecosystems

open access: yesJournal of Innovation Management, 2016
The Consortium for Research and Innovation in Aerospace in Quebec (CRIAQ) and the Consortium for Aerospace Research and Innovation in Canada (CARIC) are organizations whose missions are to facilitate collaboration of researchers from the aerospace ...
Cedric Prince   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Success factor to be an excellent project manager [PDF]

open access: yes, 2010
In general,the project manager is responsible for the overall success of the project.In some companies,this person might be called a Project Coordinator,or a Team Leader,however,the key aspect is that the person is responsible for ensuring the success of
Nurul Nadia, Abd Karim
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Challenges faced by architect as a project manager

open access: yes, 2013
One of the main concerns of the client is to see that the project completes on time, within the required cost and quality. In the construction industry, civil engineers, mechanical engineers, and architect can be as project manager who each one has ...
Ghasemi, Mohammad Mir
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Project Management - Then And Now [PDF]

open access: yesAnnales Universitatis Apulensis Series Oeconomica, 2011
The article analyzes the strategic importance of the project management, that ability of managers to manage projects consistently and competently, being considered a strategic competence. It is also analysed the change of project management vision in terms of the manager's role and responsibility, the necessary knowledge, the clients' expectations and ...
openaire   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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