Results 81 to 90 of about 570,166 (312)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Effectiveness of an educational asthma management program (CuidAR): the protocol for a cluster-randomized trial in the Brazilian primary healthcare setting

Trials
Background Asthma is one of the most prevalent chronic pulmonary diseases, affecting approximately 20 million Brazilian people. Most patients with asthma in Brazil present with uncontrolled disease, leading to high morbidity and mortality rates ...
Ana Paula Tussi Leite, Géssica Luana Antunes, Amanda Paz Santos, Ingrid Rodrigues Fernandes, Lauren Sezerá Costa, Tássia Rolim Camargo, Camila Bonalume Dall’ Aqua, Fernando Rovedder Boita, Alessandra da Silva Mota, Mariana Motta Dias da Silva, Mariah Prata Soldi Passos Taube, Bruna Silveira da Rosa, Marcus Herbert Jones, Álvaro A. Cruz, Frederico Friedrich, Paulo M. Pitrez   +15 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Risk Assessment of the Project to Migrate to the Free Office Suite Under Linux "End-User" Group [PDF]

The penetration and performance of free software is raising issues regarding its true capacities and, particularly, the desirability of choosing it. It is from this perspective that the Linux Migration Project was launched within the Sous-secrétariat à l’
Suzanne Rivard, Malika Aboubekr
core  

The youth need chemistry, chemistry needs the youth

LUMAT, 2013
During ChemBio 2013 event there was a panel discussion under the topic ”What the youth need chemistry for?” From the viewpoint of chemical industry, the answer is clear.
Riitta Talvenlahti
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Other title: Project Linking Individuals Not Known

, 2015
Palm card.; "Mike DeWine, Ohio Attorney General."; "Created: 11/6/2015..."--Document properties screen.; "Protecting Ohio's Families."; Harvested from the web on 11/12/15How to use Project LINK to identify remains -- What will happen -- How to use ...

core  

Low Measles Vaccination Coverage and Spatial Analysis of High Measles Vaccination Dropout in Ethiopia’s Underprivileged Areas

Vaccines
(1) Background: Measles remains a major cause of disease and death worldwide, especially in the World Health Organization African Region. This study aimed to estimate the coverage of measles vaccinations and map the spatial distribution of measles ...
Fisseha Shiferie, Samson Gebremedhin, Gashaw Andargie, Dawit A. Tsegaye, Wondwossen A. Alemayehu, Teferi Gedif Fenta   +5 more
doaj   +1 more source