Results 31 to 40 of about 1,202,578 (267)

Influence in-sourcing and outsourcing of consultants on construction project performance in Nigeria

Construction Economics and Building, 2011
Research studies have discovered that outsourcing has several benefits and the practice is fast replacing in-sourcing especially with regard to construction consultants.
Godwin Iroroakpo Idoro
doaj   +1 more source

A Change Management Approach with the Support of the Balanced Scorecard and the Utilization of Artificial Neural Networks

Administrative Sciences, 2022
Artificial Intelligence (AI) has revolutionized the way organizations face decision-making issues. One of these crucial elements is the implementation of organizational changes. There has been a wide-spread adoption of AI techniques in the private sector,
Alkinoos Psarras, Theodoros Anagnostopoulos, Ioannis Salmon, Yannis Psaromiligkos, Lazaros Vryzidis   +4 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Exploring cross-project building performance prediction: creation and implementation of a zone-based surrogate model for building performance optimization [PDF]

, 2023
Artem Verkhovskiy, Abraham Yezioro, Isaac Guedi Capeluto   +2 more
openalex   +1 more source

The Impact of Artificial Intelligence on Organizational Justice and Project Performance: A Systematic Literature and Science Mapping Review

Buildings
By adopting a systematic literature and science mapping review, this paper aims to explore the impact of artificial intelligence (AI) on organizational justice and project performance.
Xinran Zhang, Maxwell Fordjour Antwi-Afari, Yongcheng Zhang, Xuejiao Xing   +3 more
doaj   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Requirements definition and management practice to improve project outcomes / Reikalavimų apibrėžimas ir vadyba gerinant projekto rezultatus

Journal of Civil Engineering and Management, 2012
Poor project requirements definition and management (RDM) is one of the major causes of project failure. However, many organizations do not adequately manage a project's requirements leading to a poor design basis.
Li-Ren Yang, Jieh-Haur Chen, Chung-Fah Huang   +2 more
doaj   +1 more source