Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
CREATION OF OPTIMAL PERFORMANCE OF AN INVESTMENT PROJECT
The selection of an investment project is formulated as a multi-criteria decision-making problem. This paper presents a case in which the decision-maker uses nine criteria or rather attributes (Net Present Value, Internal Rate of Return, Payback Period, Accounting Rate of Return, Cumulative Cash Flows, Return on Investment, Net Profit Margin, Interest ...
Vojvodić Rosenzweig, Višnja +1 more
openaire +6 more sources
The Australian Government performance measurement and reporting framework - pilot project to audit key performance indicators [PDF]
This report presents the results of a key perfomance indicator (KPI) audit pilot project, which was designed to assess the status of the Australian Government performance measurement and reporting framework.The report concludes that it is time for ...
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The contemporary quarrel between performance and literature : reflections on performance (and) philosophy [PDF]
This article argues for an understanding of performance as being motivated by a principle of autotelicity that suspends all considerations other than those of the performance itself as it unfolds in creative free play.
James Corby, Corby, James
core +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Innovation stimulants, innovation capacity, and the performance of capital projects
. Identifying the critical determinants of innovation performance is crucial. However, few studies explore and quantify systematically the relationships between innovation factors and the performance of capital projects.
Hong Long Chen
doaj +1 more source
Influence of Stakeholders Involvement on Development Project Performance in Guinea
Stakeholder involvement plays an important and critical role in project performance. In Guinea, the Administration and Control of Major Projects and Public Procurement (ACMPPP) has initiated a huge reforms and reorganizations of development projects ...
Sékou Magassouba +3 more
semanticscholar +1 more source
Humanitarian supply chain performance management: a systematic literature review [PDF]
Purpose - The main purposes of this study are 1) to identify the state of the art of performance measurement and management in humanitarian supply chains, 2) to categorize performance measurement indicators in the five supply chain phases of Gunasekaran ...
Klumpp, Matthias +10 more
core +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Performance indicators in community health: development of a process. Final project report.
Working Group members include: Lyndall Fowler, Haeather Gale, Joanne Gell, Peter Higgins, Kate Humphries, Gwyn Jolley, Angela Littleford, Alan Lohf, Penny Markham, Raven North, Pat Pearson, Santi Reeves, Diedre Searcy, Clare Shuttleworth, Chris ...
Performance Indicators in Community Health Project Working Group
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