Results 91 to 100 of about 1,601,504 (303)

The SIMPSONS project: An integrated Mars transportation system [PDF]

open access: yes
In response to the Request for Proposal (RFP) for an integrated transportation system network for an advanced Martian base, Frontier Transportation Systems (FTS) presents the results of the SIMPSONS project (Systems Integration for Mars Planetary Surface
Allen, Kent   +8 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Agility in the management of graduation projects

open access: yesRevista MENDIVE, 2022
In university contexts, new situations emerge that underpin innovations. The article presents an agile strategy based on SCRUM practices (as a project management methodology).
Sonia Itati Mariño, Pedro Luis Alfonzo
doaj  

“Narrativas de vida y memorias”: conflicto escolar en el Colegio Santa Librada

open access: yesRevista Latinoamericana en Ciencias Sociales, Niñez y Juventud, 2014
This short, descriptive article is a response to my proposal of generating a link between the macro project “School Conflicts and Violence. The case of the Santa Librada School”; the cultural debate that studies the youth identities and a new Cali ...
Natalia María Ramírez-López
doaj   +1 more source

An Overview of a Grid Architecture for Scientific Computing

open access: yes, 2002
This document gives an overview of a Grid testbed architecture proposal for the NorduGrid project. The aim of the project is to establish an inter-Nordic testbed facility for implementation of wide area computing and data handling.
Ellert, M.   +4 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Teacher training and the use of digital information and communication technologies in mathematics classes in basic

open access: yesRevista Internacional de Formação de Professores, 2018
The current article has the objective of presenting results of a proposal of docent formation for the use digital technologies of information and communication inside mathematics classes, by using software GeoGebra.
Danilo Augusto Ferreira de Jesuz   +3 more
doaj  

GHG emissions of green coffee production : toward a standard methodology for carbon footprinting : report [PDF]

open access: yes
In this project, the scope for product specific rules for carbon footprinting of (green) coffee is investigated and a proposal is drafted for further work toward actual definition and implementation of such a ...
Sevenster, M., Verhagen, A.
core   +2 more sources

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