Results 211 to 220 of about 237,675 (304)
Advanced Science, EarlyView.TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin +11 more
wiley +1 more source
Teaching interprofessional competency in graduate education and training - implementation and evaluation of a case-based, interprofessional online seminar for pharmacists and physicians specializing in general practice. [PDF]
GMS J Med EducGehrke-Beck S +3 more
europepmc +1 more source
Advanced Science, EarlyView.Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh +8 more
wiley +1 more source
Creating a Cardio-Obstetrics Elective as a Fellow in Training. [PDF]
JACC Case RepVarma B +5 more
europepmc +1 more source
Advanced Science, EarlyView.Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari +3 more
wiley +1 more source
An improved translational approach to studying persistence-strengthening effects of differential reinforcement of alternative behavior. [PDF]
J Exp Anal BehavLayton KL, Edwards TL, Foster TM.
europepmc +1 more source
Advanced Science, EarlyView.A physics‐informed property‐bridging framework links high‐throughput hardness screening to tensile performance in quenching and partitioning steels. By transferring metallurgically guided representations across properties, a single alloy composition is designed to achieve multiple strength grades through heat‐treatment tuning alone, offering a ...
Xiaolu Wei +7 more
wiley +1 more source
Sparsity and memory constraints interact with training sequence to bias learning of associative maps. [PDF]
NeuropsychologiaNoh SM +5 more
europepmc +1 more source
A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance
Advanced Science, EarlyView.A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang +9 more
wiley +1 more source
Developing and validating machine learning models to predict vaccine hesitancy and literacy among adults in the United States. [PDF]
Front Public HealthZheng Y +7 more
europepmc +1 more source