Results 141 to 150 of about 520,390 (301)

Incorporation of Fuzzy Sets and Earned Value Management into a Cost-Time Trade-off Model

open access: yesمدیریت تولید و عملیات, 2014
Time-cost trade-off (TCT) problem is a well-known subject in the project scheduling contexts. None of previous studies in this area of research emphasize on the incorporation of the TCT problem into the started project’s performance in order to present a
Mostafa Salari   +3 more
doaj  

Heuristic procedures for reactive project scheduling. [PDF]

open access: yes
This paper describes new heuristic reactive project scheduling procedures that may be used to repair resource-constrained roject baseline schedules that suer from multiple activity duration disruptions during project execution.The objective is to ...
Ballestin, F   +3 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Stability and resource allocation in project planning. [PDF]

open access: yes
The majority of resource-constrained project scheduling efforts assumes perfect information about the scheduling problem to be solved and a static deterministic environment within which the pre-computed baseline schedule is executed.
Herroelen, Willy, Leus, Roel
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

A classification of predictive-reactive project scheduling procedures. [PDF]

open access: yes
The vast majority of the project scheduling research efforts over the past several years have concentrated on the development of workable predictive baseline schedules, assuming complete information and a static and deterministic environment.
Demeulemeester, Erik   +2 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Resource-constrained project scheduling. [PDF]

open access: yes
: Resource-constrained project scheduling involves the scheduling of project activities subject to precedence and resource constraints in order to meet the objective(s) in the best possible way. The area covers a wide variety of problem types.
Demeulemeester, Erik, Herroelen, Willy
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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