Results 151 to 160 of about 520,390 (301)

Project scheduling problem with resource constraints and activities interruption using Bees algorithm

open access: yesInternational Journal of Industrial Engineering and Production Research, 2018
Project scheduling problem with resources constraint is a well-known problem in the field of project management. The applicable nature of this problem has caused the researchers’ tendency to it. In this study, project scheduling with resource constraints
Rana Imannezhad, Soroush Avakh Darestani
doaj  

A novel class of scheduling policies for the stochastic resource-constrained project scheduling problem. [PDF]

open access: yes
We study the resource-constrained project scheduling problem with stochastic activity durations. We introduce a new class of scheduling policies for this problem, which make a number of a-priori sequencing decisions in a pre-processing phase, while the ...
Aryanezhad, Mir-Bahador   +2 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

A space station onboard scheduling assistant [PDF]

open access: yes
One of the goals for the Space Station is to achieve greater autonomy, and have less reliance on ground commanding than previous space missions. This means that the crew will have to take an active role in scheduling and rescheduling their activities ...
Anderson, B. H., Brindle, A. F.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

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