Results 71 to 80 of about 698,644 (287)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Poetic Examination of Spatial Experience: Suprematist Composition No. 1, Black on Grey by Kristina Leko

Ars & Humanitas, 2018
The paper analyses the concept of space in contemporary art on the example of Suprematist Composition No. 1, Black on Grey by Kristina Leko from 2008. Referring to Malevich’s suprematism, in December 2008 Leko initiated a project of art intervention in ...
Katarina Rukavina
doaj   +1 more source

Increasing Identification and Follow-Up of Older Adult Depression in Primary Care

Journal of Primary Care & Community Health, 2023
Introduction: Depression is a common mental health disorder faced by older adults that can go undetected and untreated. It was determined that the project site was not screening for depression among their older patient population.
Keirstin E. Uomoto
doaj   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Urban Renewal and Mobility: The Batata Square Project

Procedia - Social and Behavioral Sciences, 2014
AbstractThe City of São Paulo has a legal instrument called Urban Operation, which allows a developer to build above the statutory limit within the Master Plan in exchange for buying municipal bonds. Therefore, this revenue is allocated towards infrastructure improvements within the UO area.The Batata Square Urban Renewal Project, described in this ...
Tito Lívio Frascino, Jaime Waisman, Gabriel Feriancic   +2 more
openaire   +2 more sources

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Wetland square, market Pier: Designing for heritage in the New Zealand regional landscape

Interstices, 2016
Supervisors: Sam Kebbell, Martin Bryant This design-led research project addresses the rapid environmental degradation and socioeconomic decline to which many of New Zealand's low-lying swampland regions have succumbed.
Rachel Sari-Dewi Murray, Sam Kebbell, Martin Bryant   +2 more
doaj   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Square Kilometer Array project status report

Ground-based and Airborne Telescopes VII, 2018
This paper will describe the progress of the SKA-1 Telescope during the period from Preliminary Design Review to Critical Design Review. In addition to this, it will provide information on the management of the project with respect to managing cost and scope whilst working within a fixed cost cap.
McPherson, A.M., McMullin, J., Stevenson, T., Dewdney, P., Casson, A., STRINGHETTI, LUCA, Deegan, M., Hekman, P., Austin, M., Harman, M., Gibbs, P., Van Es, A., Labate, M.-G., Swart, G., Ciaizzo, M., Hayden, D., Turner, W.   +16 more
openaire   +3 more sources