Results 51 to 60 of about 3,426,932 (311)

Partnering Project Success Criteria in Malaysia [PDF]

open access: yes, 2008
Partnering is used as an approach in the procurement system as it could lead towards improving the performance of the construction industry. Organizations which used the partnering approach in their past construction projects are now reporting ...
Adnan, Hamimah, Jusoff, Kamaruzaman
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Model of driving factors for success in public health project management using structural equation modeling

open access: yesScientific Reports
In a context where pandemic crises and chronic conditions are a constant and increasing threat, the success of public health projects is absolutely critical.
Carolina Santos   +3 more
doaj   +1 more source

Ladder to success – eliciting project managers’ perceptions of IS project success criteria

open access: yesInternational Journal of Information Systems and Project Management, 2022
The traditional approach to assess information system (IS) project success is adherence to planning (ATP) – meeting budget, schedule, and requirements targets.
Oleg Pankratz, Dirk Basten
doaj  

Re-imagining the Iron Triangle: Embedding Sustainability into Project Constraints [PDF]

open access: yes, 2013
Since the emergence of the formal discipline of project management, academics and practitioners have sought to define criteria against which project success can be measured.
Ebbesen, Jonas Balshoej, Hope, Alex
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

open access: yesMolecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek   +2 more
wiley   +1 more source

Information systems project management success

open access: yesInternational Journal of Information Systems and Project Management, 2021
The purpose of this paper is to give new insights into the success of information systems (IS) project management. Even though many studies found in the literature show results of software development projects, few studies address the success of IS ...
João Varajão   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

open access: yesFEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima   +4 more
wiley   +1 more source

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