Results 121 to 130 of about 9,950,996 (311)

SOFT Development of feature tracking methods [PDF]

open access: yes, 2003
The present report describes the work carried out within task 3.1 of Work Package 3 of the SOFT Project. The above task is ‘Development of feature tracking methods’ and consists of the development of a software to track large-scale, westward propagating ...
Challenor, Peter, Cipollini, Paolo
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Utilizing the Project Method for Teaching Culture and Intercultural Competence [PDF]

open access: yes, 2017
This article presents a detailed methodological outline for teaching culture through project work. It is argued that because project work makes it possible to gain transferrable and applicable knowledge and insight, it is the ideal tool for teaching ...
Euler, Sasha S.
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Managing Knowledge in Project Environments [PDF]

open access: yes, 2012
Projects ought to be vehicles for both practical benefits and organizational learning. However, if an organization is designed for the long term, a project exists only for its duration.
Serrat, Olivier
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Using Project Work to Develop and Practice Writing Skills

open access: yesHOW, 2016
Any schoolteacher knows that probably one of the most difficult skills to develop when working with teenagers is writing, no matter the learners' age or proficiency level. It is usually seen as the "boring skill".
Raúl Alberto Mora
doaj  

Ghana airborne geophysics project in the Volta and Keta Basin : BGS final report [PDF]

open access: yes, 2009
This report describes the work undertaken by BGS between November 2006 and March 2009 in collaboration with Fugro Airborne Surveys Pty Ltd on an airborne geophysical survey and ground reconnaissance mapping of the Volta River and Keta Basins, Ghana ...
Carney, J.N.   +3 more
core  

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