Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Patient Empowerment in the Context of Outpatient Surgery Using the Example of Orthopedics (Power-AOP): Protocol for a Mixed Methods Study. [PDF]
Giebel GD +14 more
europepmc +1 more source
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
Patient and Public Involvement (PPI) in lab-based research. What is the added value? Reflections from a researcher and public contributor perspective. [PDF]
Hatch S, Formosa N.
europepmc +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Strengthening the organizational health literacy capacity of community-based organizations to support COVID-19 precautionary behaviors in marginalized communities. [PDF]
Fleary SA +3 more
europepmc +1 more source
Ten simple rules for teaching data science. [PDF]
Timbers TA, Çetinkaya-Rundel M.
europepmc +1 more source
Practical model for workforce development and community engagement in the public health laboratory. [PDF]
Galusha AL +13 more
europepmc +1 more source
The medical peace work-project
openaire +3 more sources

