Results 81 to 90 of about 9,950,996 (311)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

DEVELOPMENT OF PROFESSIONAL SKILLS OF DESIGN STUDENTS DURING REFLEXIVE ANALISIS WORK ON THE PROJECT

open access: yesSovremennye Issledovaniâ Socialʹnyh Problem, 2015
Search for new approaches in vocational training is the result of the new requirements for the training of graduates. Because in this period of life is formed worldview, self-determination, behavior and communication, the methods and techniques of ...
Olga Leovna Salikhova
doaj   +1 more source

International Research Project on Job Retention and Return to Work Strategies for Disabled Workers: Germany [PDF]

open access: yes, 1998
[Excerpt] The International Research Project on Job Retention and Return to Work Strategies for Disabled Workers is an initiative of the International Labour Organisation (ILO) and the Global Applied Research and Information Network on Employment and ...
Albrecht, Martin, Braun, Hans
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

USING PROJECT WORK IN TEACHING ENGLISH FOR SPECIFIC PURPOSES FOR ENERGY SE [PDF]

open access: yesВісник Університету імені Альфреда Нобеля. Серія Педагогіка і психология
This paper aims to investigate the efficacy of project-based learning in teaching English for specific purposes, particularly in technical universities within the energy sector. A number of methods helped to achieve this task. They include establishing
Vilkhovchenko Nadiia
doaj   +1 more source

Knowledge management in project-base organizations: the interplay of time orientations and knowledge interventions [PDF]

open access: yes, 2007
The common perception is that all types of work and work organizations appear to involve knowledge: knowledge intensive work, knowledge workers, knowledge products, customerrelated knowledge and knowledge intensive organizations.
Manfredi, Filippo   +1 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Work Project

open access: yes, 2022
The aim of this Report is to describe the different stages of work that the team representing NOVA University in the 29th edition of the Willem C. Vis Moot Competition of 2022 went through in the past seven months of this project. In this Report, the Team will provide an overview of Willem C. Vis Moot followed by a detailed explanation of each member’s
openaire   +1 more source

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