Results 91 to 100 of about 439,416 (273)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

A Theorem of Nehari Type on Weighted Bergman Spaces of the Unit Ball

open access: yesAbstract and Applied Analysis, 2008
This paper shows that if S is a bounded linear operator acting on the weighted Bergman spaces Aα2 on the unit ball in ℂn such that STzi=Tz¯iS (i=1,…,n), where Tzi=zif and Tz¯i=P(z¯if); and where P is the weighted Bergman projection, then S must be a ...
Yufeng Lu, Jun Yang
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Some Sharp L^2 Inequalities for Dirac Type Operators

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2007
We use the spectra of Dirac type operators on the sphere $S^n$ to produce sharp $L^2$ inequalities on the sphere. These operators include the Dirac operator on $S^n$, the conformal Laplacian and Paenitz operator.
Alexander Balinsky, John Ryan
doaj  

Strong convergence theorems by hybrid and shrinking projection methods for sums of two monotone operators

open access: yesJournal of Inequalities and Applications, 2017
In this paper, we introduce two iterative algorithms for finding the solution of the sum of two monotone operators by using hybrid projection methods and shrinking projection methods.
Tadchai Yuying, Somyot Plubtieng
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Random walks in disordered lattice, CTRW, memory and dipole transport [PDF]

open access: yesMagnetic Resonance in Solids, 2017
Application of CTRW (continuous time random walks) to dipole hopping transport is reviewed. Conditions of applicability of basic kinetic equations to spin systems are indicated.
F.S. Dzheparov
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

The Shrinking Projection Method for Solving Variational Inequality Problems and Fixed Point Problems in Banach Spaces

open access: yesAbstract and Applied Analysis, 2009
We consider a hybrid projection algorithm based on the shrinking projection method for two families of quasi-ϕ-nonexpansive mappings. We establish strong convergence theorems for approximating the common element of the set of the common fixed points of
Rabian Wangkeeree   +1 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

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