Results 161 to 170 of about 353,264 (267)

Genoarchitecture and input-output organization of the mouse basal ganglia and thalamic parafascicular nucleus. [PDF]

Nat Neurosci
Wang Q, Bhandiwad A, Gouwens NW, Yao S, Wang Y, Kuang X, Li A, Li X, Dalley R, Kuo HC, Lesnar P, Xu W, Mallory M, Li Y, El-Hifnawi L, Ahmadinia L, Ouellette B, Kruse L, Ng L, Gong H, Luo Q, Kunst M, van Velthoven CTJ, Yao Z, Sorensen SA, Zeng H.   +25 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Effect of spatial resolution and heating duration on accuracy of dynamic proton resonance frequency shift temperature measurement with k-space weighted image contrast reconstruction during focused ultrasound. [PDF]

Magn Reson Imaging
Richards N, Malmberg M, Odéen H, Merrill R, Hadley R, Parker DL, Payne A.   +6 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Modeled Scenario Projections for the Ebola Disease Outbreak Caused by Bundibugyo Virus, 2026. [PDF]

MMWR Morb Mortal Wkly Rep
Mooring EQ, Koval WT, Routledge I, Holmdahl I, Hudson K, España G, Kahn R, Bruce BB.   +7 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

A Functional Trait-Based Approach to Mapping Climate-Driven Changes in Temperature-Dependent Feeding Suitability. [PDF]

Ecol Evol
Marchessaux G, Aksu S, Tarkan AS.
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Perirhinal cortex gains control of hippocampal seizures via broad downstream circuits in male mouse models. [PDF]

Nat Commun
Li Z, Lu W, Sun Y, Xi J, Chen J, Lai N, Shao Y, Fei F, Cheng H, Chen Z, Wang Y.   +10 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source