Results 41 to 50 of about 114,860 (221)

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Special Kähler geometry and holomorphic Lagrangian fibrations

open access: yesComptes Rendus. Mathématique
Given a holomorphic Lagrangian fibration of a compact hyperkähler manifold, we use the differential geometry of the special Kähler metric that exists on the base away from the discriminant locus, and show that the pullback of the tangent bundle of the ...
Li, Yang, Tosatti, Valentino
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Differential geometry with a projection: application to double field theory [PDF]

open access: yesJournal of High Energy Physics, 2011
1+22 pages, No figure; a previous result on 4-index tensor removed, presentation ...
Imtak Jeon   +2 more
openaire   +4 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

GEOMETRY – AN IMPORTANT MEANS OF EDUCATION IN THE CIVILISATION SCOPE

open access: yesJournal of Industrial Design and Engineering Graphics, 2017
Geometry (from the Greek: γεωμετρία; geo = earth, metria = measure) is a genuine science, rooted in mathematics, which studies the plane and spatial forms of bodies from the objective or conceptual reality and the nature of the relationship that exists ...
Liliana TOCARIU, PhD
doaj  

Tangency quantum cohomology and characteristic numbers

open access: yesAnais da Academia Brasileira de Ciências, 2001
This work establishes a connection between gravitational quantum cohomology and enumerative geometry of rational curves (in a projective homogeneous variety) subject to conditions of infinitesimal nature like, for example, tangency.
JOACHIM KOCK
doaj   +1 more source

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