Results 41 to 50 of about 131,999 (262)
GEOMETRY – AN IMPORTANT MEANS OF EDUCATION IN THE CIVILISATION SCOPE
Journal of Industrial Design and Engineering Graphics, 2017 Geometry (from the Greek: γεωμετρία; geo = earth, metria = measure) is a genuine science, rooted in mathematics, which studies the plane and spatial forms of bodies from the objective or conceptual reality and the nature of the relationship that exists ...
Liliana TOCARIU, PhD
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Positive geometries and canonical forms
Journal of High Energy Physics, 2017 Recent years have seen a surprising connection between the physics of scattering amplitudes and a class of mathematical objects — the positive Grassmannian, positive loop Grassmannians, tree and loop Amplituhedra — which have been loosely referred to as “
Nima Arkani-Hamed +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Differentiable Manifolds and Geometric Structures
MathematicsThis editorial presents 26 research articles published in the Special Issue entitled Differentiable Manifolds and Geometric Structures of the MDPI Mathematics journal, which covers a wide range of topics particularly from the geometry of (pseudo ...
Adara M. Blaga
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Differential geometry with a projection: application to double field theory [PDF]
Journal of High Energy Physics, 2011 1+22 pages, No figure; a previous result on 4-index tensor removed, presentation ...
Jeon, Imtak +2 more
openaire +3 more sources
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Differential Invariants of Conformal and Projective Surfaces
Symmetry, Integrability and Geometry: Methods and Applications, 2007 We show that, for both the conformal and projective groups, all the differential invariants of a generic surface in three-dimensional space can be written as combinations of the invariant derivatives of a single differential invariant. The proof is based
Evelyne Hubert, Peter J. Olver
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