Results 41 to 50 of about 119,892 (309)
Non-Projected Supermanifolds and Embeddings in Super Grassmannians
Universe, 2018 In this paper we give a brief account of the relations between non-projected supermanifolds and projectivity in supergeometry. Following the general results (L.
Simone Noja
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Clifford algebra and the projective model of homogeneous metric spaces: Foundations [PDF]
, 2013 This paper is to serve as a key to the projective (homogeneous) model developed by Charles Gunn (arXiv:1101.4542 [math.MG]). The goal is to explain the underlying concepts in a simple language and give plenty of examples. It is targeted to physicists and
Sokolov, Andrey
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
, 2005 A contact projective structure is a contact path geometry the paths of which are among the geodesics of some affine connection. In the manner of T.Y.
Fox, Daniel J. F.
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FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Projective geometries as projective modular lattices [PDF]
Transactions of the American Mathematical Society, 1979 It is shown that the lattice of subspaces of a finite dimensional vector space over a finite prime field is projective in the class of modular lattices provided the dimension is at least 4.
openaire +2 more sources
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
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Analytic projective geometry for computer graphics
Discrete and Continuous Models and Applied Computational ScienceThe motivation of this paper was the development of computer geometry course for students of mathematical specialties. The term “computer geometry” hereafter refers to the mathematical foundations of machine graphics.
Migran N. Gevorkyan +3 more
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Metric connections in projective differential geometry
, 2008 We search for Riemannian metrics whose Levi-Civita connection belongs to a given projective class. Following Sinjukov and Mikes, we show that such metrics correspond precisely to suitably positive solutions of a certain projectively invariant finite-type
A.R. Gover +6 more
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