Results 61 to 70 of about 190,046 (323)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Universal Entire Curves in Projective Spaces with Slow Growth [PDF]

, 2023
Zhangchi Chen, Dinh Tuan Huynh, Song‐Yan Xie   +2 more
openalex   +1 more source

On projective coordinate spaces

Filomat, 2015
In the present study, an (n+1)-dimensional module over the local ringK = Mmm(R) is constructed. Further, an n-dimensional projective coordinate space over this module is constructed with the help of equivalence classes. The points and lines of this space are determined and the points are classified.
Erdogan, FATMA, Ciftci, Suleyman
openaire   +4 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Machine Translation by Projecting Text into the Same Phonetic-Orthographic Space Using a Common Encoding [PDF]

, 2023
Amit Kumar, Shantipriya Parida, Ajay Pratap, A. K. Singh   +3 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Neural Network-Based Projective Grid Model for Learning Representation of Surface and Wave Foams

IEEE Access
In this paper, we propose a projective grid model that enables learning representation of foam effects using artificial neural networks. In 3D fluid simulations, foam is one of the most representative secondary effects in water.
Jong-Hyun Kim
doaj   +1 more source

On geometry of orbits of adapted projective frame space

Дифференциальная геометрия многообразий фигур, 2019
The current paper continues consideration of geometry of projective frame orbits started in the author’s article in the previous issue. The n-dimensional projective space with a distinguished point (the center) is considered.
A. Kuleshov
doaj   +1 more source

The block structure spaces of real projective spaces and orthogonal calculus of functors

, 2006
Given a compact manifold X, the set of simple manifold structures on X x \Delta^k relative to the boundary can be viewed as the k-th homotopy group of a space \S^s (X). This space is called the block structure space of X.
Macko, Tibor
core