Results 61 to 70 of about 179,771 (272)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
On geometry of orbits of adapted projective frame space
Дифференциальная геометрия многообразий фигур, 2019 The current paper continues consideration of geometry of projective frame orbits started in the author’s article in the previous issue. The n-dimensional projective space with a distinguished point (the center) is considered.
A. Kuleshov
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Neural Network-Based Projective Grid Model for Learning Representation of Surface and Wave Foams
IEEE AccessIn this paper, we propose a projective grid model that enables learning representation of foam effects using artificial neural networks. In 3D fluid simulations, foam is one of the most representative secondary effects in water.
Jong-Hyun Kim
doaj +1 more source
Relativistic Localizing Processes Bespeak an Inevitable Projective Geometry of Spacetime
Advances in High Energy Physics, 2017 Surprisingly, the issue of events localization in spacetime is poorly understood and a fortiori realized even in the context of Einstein’s relativity.
Jacques L. Rubin
doaj +1 more source
The block structure spaces of real projective spaces and orthogonal calculus of functors
, 2006 Given a compact manifold X, the set of simple manifold structures on X x \Delta^k relative to the boundary can be viewed as the k-th homotopy group of a space \S^s (X). This space is called the block structure space of X.
Macko, Tibor
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source