Results 91 to 100 of about 488,150 (337)

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Mapping spaces from projective spaces [PDF]

Homology, Homotopy and Applications, 2016
26 pages, 3 figures; the appendix in v3 is deleted since its argument was ...
openaire   +4 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Isomorphism of Multiprojective Bundles and Projective Towers [PDF]

arXiv, 2023
We study when two projective bundles over two arbitrary smooth projective varieties of different dimensions can be isomorphic. We show that two multi-projective bundles (fibre product of projective bundles) over different projective spaces cannot be isomorphic, except in the trivial case.
arxiv  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Contractive projections and operator spaces [PDF]

Comptes Rendus de l'Académie des Sciences - Series I - Mathematics, 2000
Parallel to the study of finite-dimensional Banach spaces, there is a growing interest in the corresponding local theory of operator spaces. We define a family of Hilbertian operator spaces H n k H_n^k , 1 ≤ k ≤ n 1\le k\le n , generalizing the row and column ...
Neal, Matthew, Russo, Bernard
openaire   +7 more sources

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

SOME FEATURES OF PAIRWISE α-R0 SPACES IN SUPRA FUZZY BITOPOLOGY [PDF]

Journal of Mechanics of Continua and Mathematical Sciences
This paper introduces and studies four concepts of 𝑅0 supra fuzzy bitopological spaces. We have exhibited that all these four concepts are ‘good extensions’ of the corresponding concepts 𝑅0 bitopological spaces and building relationships among them.
Md. Hannan Miah, Ruhul Amin
doaj   +1 more source

Characterizations of projective spaces and hyperquadrics [PDF]

Asian Journal of Mathematics, 2013
In this paper we prove that if the r-th tensor power of the tangent bundle of a smooth projective variety X contains the determinant of an ample vector bundle of rank at least r, then X is isomorphic either to a projective space or to a smooth quadric hypersurface.
Druel, Stéphane, Paris, Matthieu
openaire   +4 more sources

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source