Results 131 to 140 of about 7,721 (290)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Projective integration of expensive stochastic processes

, 2011
The 15th Biennial Computational Techniques and Applications Conference, held at the University of New South Wales, 28 November - 1 December 2010Consider the case when a microscale simulator is too expensive for long time simulations necessary to ...
Kevrekidis, I., Chen, Xiaopeng, Roberts, Anthony J., Roberts, A., Chen, X., Kevrekidis, Ioannis   +5 more
core  

O uso de procedimentos projetivos na pesquisa de representações sociais: projeção e transicionalidade

Psicologia USP
O artigo propõe o estudo das representações sociais a partir da perspectiva psicodinâmica. Considera que a utilização de métodos projetivos tem-se revelado uma alternativa promissora de pesquisa, abordando-os como metodologia clínica sofisticada, que ...
Tânia Maria José Aiello-Vaisberg
doaj  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Parallel submanifolds of complex projective space and their normal holonomy [PDF]

, 2009
S. CONSOLE, Console, S., Di Scala, Antonio Jose'   +2 more
core  

The use of projective techniques to circumvent socially desirable responses or reveal the subconscious.

, 2017
Projective techniques have considerable potential to study consumer behaviour and are widely used in commercial market research and psychology, but not in tourism and hospitality research.
Hindley, Ann, Font, Xavier
core  

Exploring the Role of Projective Techniques in Modern Personality Assessment: Balancing Subjectivity and Objectivity

This study employs a qualitative meta-analytic approach to examine the continuing relevance of classical projective techniques and psychodynamic theories in contemporary clinical practice.
Orji, Leonard C., Ishola, Ajibola Abdulrahamon, Uzodinma, Emmanuel E.   +2 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Impact of therapeutic play and music therapy on dental anxiety and pain perception in pediatric patients: a clinical study. [PDF]

Sci Rep
Kabasakal HN, Aydınoğlu S, Günaçar DN.   +2 more
europepmc   +1 more source