Results 51 to 60 of about 17,189,290 (335)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

The House-Tree-Person test is not valid for the prediction of mental health: An empirical study using deep neural networks

open access: yesActa Psychologica, 2022
As one of the projective drawing techniques, the House-Tree-Person test (HTP) has been widely used in psychological counseling. However, its validity in diagnosing mental health problems remains controversial.
Yijing Lin   +5 more
doaj   +1 more source

Directions and projective shapes

open access: yes, 2005
This paper deals with projective shape analysis, which is a study of finite configurations of points modulo projective transformations. The topic has various applications in machine vision.
Mardia, Kanti V., Patrangenaru, Vic
core   +1 more source

General method for constructing local-hidden-variable models for entangled quantum states [PDF]

open access: yes, 2016
Entanglement allows for the nonlocality of quantum theory, which is the resource behind device-independent quantum information protocols. However, not all entangled quantum states display nonlocality, and a central question is to determine the precise ...
Cavalcanti, Daniel   +3 more
core   +2 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Projections of Tropical Fermat-Weber Points

open access: yesMathematics, 2021
This paper is motivated by the difference between the classical principal component analysis (PCA) in a Euclidean space and the tropical PCA in a tropical projective torus as follows.
Weiyi Ding, Xiaoxian Tang
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

CCT4 promotes tunneling nanotube formation

open access: yesFEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto   +3 more
wiley   +1 more source

Assessment of the recreational transformation of the grass cover of public green spaces

open access: yesAgrology, 2021
The paper reveals regularities of grass projective cover variation depending on the level of recreational transformation of public green spaces, taking into account stand density and soil electrical conductivity.
N. V. Yorkina   +6 more
doaj   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

open access: yesFEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji   +3 more
wiley   +1 more source

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