In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Probing strategy-project alignment: The case of the South African Social Security Agency
Public institutions, such as the South African Social Security Agency (SASSA) increasingly function in multi-project environments to translate strategies successfully into service-delivery initiatives.
Gerrit Van Der Waldt
doaj +1 more source
New Labour, new environment? An analysis of the labour government's policy on climate change and biodiversity loss [PDF]
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Carter, Neil, Ockwell, David
core
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
LSUN: Construction of a Large-scale Image Dataset using Deep Learning with Humans in the Loop [PDF]
While there has been remarkable progress in the performance of visual recognition algorithms, the state-of-the-art models tend to be exceptionally data-hungry.
Funkhouser, Thomas +5 more
core
A mass-loss rate determination for zeta Puppis from the quantitative analysis of X-ray emission line profiles [PDF]
We fit every emission line in the high-resolution Chandra grating spectrum of zeta Pup with an empirical line profile model that accounts for the effects of Doppler broadening and attenuation by the bulk wind.
Asplund +64 more
core +7 more sources
BackgroundAccess to mobile phone technology has rapidly expanded in developing countries. In Africa, mHealth is a relatively new concept and questions arise regarding reliability of the technology used for health outcomes. This review documents strengths,
Clara B. Aranda-Jan +2 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Proposal for a technical assistance and enfineering credit for highways Republic of Korea [PDF]
노트 : This report was prepared for use within the Bank and its affiliated organizations. They do not accept responsibility for its accuracy or completeness.
The World Bank(Projects Department)
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source

