Results 151 to 160 of about 9,608,719 (352)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
A study of effective evaluation models and practices for technology supported physical learning spaces (JELS) [PDF]
, 2009 The aim of the JELS project was to identify and review the tools, methods and frameworks used to evaluate technology supported or enhanced physical learning spaces.
Bligh, Brett +6 more
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Jane Topping contributed work to this adhoc open-studio-meets-collaborative-exhibition event. Visitors could immerse themselves in Film Open, a new screening programme of artist films, featuring twenty recent works selected from an open call to Associate
Eastside Projects, Topping, Jane
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
, 2005 18 worksheets Related Documents:WC11, WC12, WC13, WC14, WC15, WC16, WC17 ...
openaire +5 more sources
, 2006 The property of presuppositions to be sometimes preserved through embeddings, albeit often in a weakened form, is called projection. The projection problem consists in formulating the conditions under which the presuppositions of an embedded clause (a) are kept as presuppositions of the superordinate structure, or (b) remain as an invited inference ...
openaire +3 more sources
Inquiries into inquiry projects [PDF]
, 2007 The projects developed by the research teams foster inquiry and leadership for the improvement of student learning and reflective teaching. They expand conceptions of learning and teaching by linking to the community, crossing disciplinary boundaries ...
Bruce, Bertram C., Graber, Kim
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source