Results 241 to 250 of about 9,608,719 (352)

Generative AI voting: fair collective choice is resilient to LLM biases and inconsistencies. [PDF]

EPJ Data Sci
Majumdar S, Elkind E, Pournaras E.
europepmc   +1 more source

Debt Composition and Balance Sheet Effects of Exchange and Interest Rate Volatility in Brazil [PDF]

Marco Bonomo
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Embedded Research in a Learning Health System: How a Research-Operations Partnership Informed the Development, Implementation, and Scaling of VA's Whole Health System. [PDF]

Learn Health Syst
Bolton R, Zeliadt SB, Hyde J, Etingen B, Anderson E, Barker A, Wu J, Kligler B, Bokhour BG.   +8 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

The educational outcomes of medical student engagement in research projects: a scoping review. [PDF]

BMC Med Educ
Stirling M, Hart J.
europepmc   +1 more source

Hell, Heaven or Hedged: Debt Devaluation and Firm Investment in Colombia [PDF]

Juan Carlos Echeverry, Leopoldo Ferguson, Roberto Steiner   +2 more
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Health systems science education for undergraduate medical students: a 3-year longitudinal curriculum preparing students to drive real-world health system improvement. [PDF]

BMC Med Educ
Popatia R, D'Silva J, Stanley A, Khan N, Ho SB, Alsheikh-Ali A.   +5 more
europepmc   +1 more source