Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Probing strategy-project alignment: The case of the South African Social Security Agency
The Journal for Transdisciplinary Research in Southern Africa, 2016 Public institutions, such as the South African Social Security Agency (SASSA) increasingly function in multi-project environments to translate strategies successfully into service-delivery initiatives.
Gerrit Van Der Waldt
doaj +1 more source
LSUN: Construction of a Large-scale Image Dataset using Deep Learning with Humans in the Loop [PDF]
, 2016 While there has been remarkable progress in the performance of visual recognition algorithms, the state-of-the-art models tend to be exceptionally data-hungry.
Funkhouser, Thomas +5 more
core
A mass-loss rate determination for zeta Puppis from the quantitative analysis of X-ray emission line profiles [PDF]
, 2009 We fit every emission line in the high-resolution Chandra grating spectrum of zeta Pup with an empirical line profile model that accounts for the effects of Doppler broadening and attenuation by the bulk wind.
Asplund +64 more
core +7 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
New Labour, new environment? An analysis of the labour government's policy on climate change and biodiversity loss [PDF]
, 2007 No description ...
Carter, Neil, Ockwell, David
core
Appraisal of Rail Projects. [PDF]
, 1992 This paper reviews the particular characteristics of rail investment projects, taking as a starting point four examples ranging from decisions on individual routes to national rail investment programmes.
Nash, C.A.
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Research, Analysis and Insight into National Standards (RAINS) Project Final Report: National Standards and the Damage Done [PDF]
, 2013 This is the final report of the Research Analysis and Insight into National Standards (RAINS) project, a three-year study of the enactment of the National Standards policy in six diverse primary and intermediate schools.
Thrupp, Martin, White, Michelle
core +3 more sources