Results 321 to 330 of about 3,456,235 (361)

Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib

ACR Open Rheumatology, EarlyView.
Objective Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is made via a trial‐and‐error strategy. A comprehensive analysis of responses to JAKi, including tofacitinib, by RNA sequencing (RNAseq) would allow the discovery of transcriptomic markers with a two‐fold ...
Chiara Bellocchi, Ennio Giulio Favalli, Gabriella Maioli, Elena Agape, Marzia Rossato, Matteo Paini, Adriana Severino, Barbara Vigone, Martina Biggioggero, Elena Trombetta, Roberto Caporali, Lorenzo Beretta   +11 more
wiley   +1 more source

miR-29a-3p compositely regulates the COL6A6/PTEN-PI3K/Akt/CUX1 feedback loop to participate in the proliferation and invasion of pituitary adenomas. [PDF]

J Mol Histol
Liu Z, Liao X, Zhao H, Ruan B, Jia F, He X, Long R.   +6 more
europepmc   +1 more source

Herbal Formula Yi‐Fei‐Jie‐Du‐Tang Regulates Epithelial‐Mesenchymal Transition and Vasculogenic Mimicry in Lung Cancer via HIF1A‐Mediated Ferroptosis

Advanced Biology, Volume 9, Issue 3, March 2025.
Yi‐Fei‐Jie‐Du‐Tang (YFJDT), a traditional Chinese medicine, has shown potential in lung cancer treatment by targeting key pathways. This study explores the mechanisms of YFJDT using bioinformatics, xenograft models, and A549 cells, demonstrating that YFJDT downregulates HIF1A, promotes ferroptosis, and inhibits epithelial‐mesenchymal transition (EMT ...
Shanshan Wang, Die Yang, Chengjia Yuan, Yang Wu, Qingying Wang, Yongjian Wu, Xiaochun Zhang   +6 more
wiley   +1 more source

Targeting PIK3CB/YAP1 improves the sensitivity of paclitaxel by suppressing aging in head and neck squamous tumor cells. [PDF]

Cancer Cell Int
Liu J, Li H, Sun R, Ying G, Liang Z.
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Current research of the Notch pathway in hepatocellular carcinoma. [PDF]

Eur J Med Res
Fu L, Gu X, Lou N, Li J, Xue C.
europepmc   +1 more source

Role of N6-methyladenosine methyltransferase component RBM15 in cancer progression and its therapeutic potential. [PDF]

Discov Oncol
Shen W, Ma Y, Yang C, Yan S, Ye K.
europepmc   +1 more source

Exosomes derived from M2 macrophage promote HUVECs proliferation, migration and tube formation in vitro. [PDF]

Sci Rep
Xue Y, Chen J, Sun X, Su C, Fan S, Song X, Deng R, Hao J.   +7 more
europepmc   +1 more source

7,7-Bis(3-Indolyl)-<i>p</i>-Cresol, a Metabolite from Marine-Derived Bacterium <i>Vibrio</i> spp. DJA11, Suppresses the Proliferation and Motility of Prostate Cancer Cells. [PDF]

J Microbiol Biotechnol
Pulat S, Lee EY, Choi G, Jung YH, Nam SJ, Kim H.   +5 more
europepmc   +1 more source

HDAC7 promotes cardiomyocyte proliferation by suppressing myocyte enhancer factor 2. [PDF]

J Mol Cell Biol
Jang J, Bentsen M, Bu J, Chen L, Campos AR, Looso M, Li D.   +6 more
europepmc   +1 more source