Results 91 to 100 of about 209,035 (336)

Moxifloxacin‐induced QT_c interval prolongations in healthy male Japanese and Caucasian volunteers: a direct comparison in a thorough QT study [PDF]

, 2015
Joel Morganroth, Yaning Wang, Michael Thorn, Yuji Kumagai, Stuart Harris, Norman Stockbridge, Robert Kleiman, Rashmi R. Shah   +7 more
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Effectiveness of Single Intravenous Dexamethasone in Prolongation of Spinal Anesthesia for Postoperative Analgesia in Elective Cesarean Section: A Systematic Review of Randomized Controlled Trials

Journal of Pain Research
Minda Abebe,1 Belete Alemu,1 Gudeta Teku,1 Oliyad Eshetu,1 Endeshaw Wale,1 Aschalew Besha,1 Mengistu Yinges Kebede,1 Lamesgen Geta2 1Department of Anesthesia, Collage of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia; 2Department of ...
Abebe M, Alemu B, Teku G, Eshetu O, Wale E, Besha A, Kebede MY, Geta L   +7 more
doaj  

Prolongation of Allograft Survival by Administration of Anti-CD45RB Monoclonal Antibody Is Due to Alteration of CD45RBhi: CD45RBlo T-Cell Proportions [PDF]

, 2006
Patrick Luke, Jianchuan Deng, D. Lian, Peta J. O’Connell, B. García, Anthony M. Jevnikar, Robert Zhong   +6 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cholinesterase inhibitors-associated torsade de pointes/QT prolongation: a real-world pharmacovigilance study

Frontiers in Pharmacology
Objective: Cholinesterase inhibitor (ChEIs) is the first-line drug for Alzheimer’s disease (AD). Understanding torsade de pointes (TdP)/QT prolongation with different ChEIs is essential for its safe and rational administration.
Ni Zhang, Lanlan Gan, Guiyuan Xiang, Jing Xu, Tingting Jiang, Yanping Li, Yuanlin Wu, Rui Ni, Yao Liu   +8 more
doaj   +1 more source

Four explicit formulas for the prolongations of an infinitesimal Lie symmetry and multivariate Faa di Bruno formulas [PDF]

, 2004
Joël Merker
openalex   +1 more source

Potential for Prolongation of Fibrinogen Concentrates Post-Reconstitution

, 2022
Robert J. Guo, Tyler Smith, David Zamar, Jacqueline D. Trudeau, Andrew W. Shih   +4 more
openalex   +1 more source