Results 121 to 130 of about 209,035 (336)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Identification of urine biomarkers predictive of prolonged QTc interval in multidrug-resistant tuberculosis patients treated with bedaquiline

Frontiers in Pharmacology
The most frequent adverse event associated with bedaquiline (BDQ) is the QTc interval prolongation; however, there was no biomarkers that could be used to predict the occurrence of QTc prolongation in BDQ-treated patients.
Jiajia Yu, Weicong Ren, Jinfeng Yuan, Rongmei Liu, Liping Ma, Shenjie Tang, Yu Pang   +6 more
doaj   +1 more source

Refus des traitements de prolongation de vie dans le cas de patients dont la mort n'est pas imminente : étude clinique et jurisprudence récente au Québec [PDF]

, 1992
DJ Roy
openalex   +1 more source

Prolonged Labour [PDF]

BMJ, 1964
openaire   +2 more sources

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.

Cardiovascular Research, 2003
W. Redfern, L. Carlsson, A. S. Davis, W. G. Lynch, I. Mackenzie, S. Palethorpe, P. Siegl, I. Strang, A. Sullivan, R. Wallis, A. Camm, T. Hammond   +11 more
semanticscholar   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Effect‐site concentration of remifentanil for attenuating QTc interval prolongation following intubation in hypertensive female patients

, 2015
Eun Jung Kim, Dong Woo Han, Mi Kyung Song, Seung‐Ho Choi, So Yeon Kim   +4 more
openalex   +2 more sources

THE NATURAL AFFINORS ON THE r-JET PROLONGATIONS OF A VECTOR BUNDLE [PDF]

, 2004
Włodzimierz M. Mikulski
openalex   +1 more source