ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann +6 more
wiley +1 more source
Modelling of clinical TQT studies outcomes from preclinical cardiovascular safety pharmacology studies using the one-step QTc model. [PDF]
Champéroux P, Fares R, Leishman D.
europepmc +1 more source
Prolongation of Canine Renal Allografts by Horse Anti-Dog Lymphocyte Serum and Globulin
A.G. Diethelm +6 more
openalex +2 more sources
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini +13 more
wiley +1 more source
QT Prolongation Following Premature Ventricular Contractions Leading to Ventricular Storms: A Case Report. [PDF]
Jalabadze K, Tsiklauri B.
europepmc +1 more source
Studies on the prolongation of marketing life of fresh fruits and vegetables. III.
Masutaro OKUBO, T. MAEZAWA
openalex +2 more sources
Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia
ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster +11 more
wiley +1 more source
Variably Defined Conduction Block, Temporal Dispersion and Other Electrophysiological Abnormalities in Multifocal Motor Neuropathy: A Multicentre Study. [PDF]
Rajabally YA +6 more
europepmc +1 more source
Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer [PDF]
Ewan Cameron, Linus Pauling
openalex +1 more source

